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Viruses apply an array of mechanisms to resist inactivation by host antibodies. Many viruses can change the structure of their proteins by mutations. Viruses can also mask conserved elements on their surface proteins or increase their structural stability. In our lab we try to understand these molecular and evolutionary evasion mechanisms to design strategies that can improve antibody-based vaccines. Two complementary research programs, molecular and computational, apply different tools from the fields of chemistry, physics, structural biology and mathematics to achieve this goal.