Principles of Virus Evolution & Transmission

Selected Publications

  1. Han C, Johnson J, Dong R, Kandula R, Kort A, Wong M, Yang T, Breheny PJ, Brown GD, Haim H. 2020. Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels. mBio 2020;11(3):e00126-20. [PMID: 32518179].

  2. Johnson J, Flores MG, Rosa J, Han C, Salvi AM, DeMali KA, Jagnow JR, Sparks A, Haim H. 2020. The high content of fructose in human semen competitively inhibits broad and potent antivirals that target high-mannose glycans. J Virol 2020;94(9):e01749-19 [PMID 32102878].

  3. Salimi H, Johnson J, Flores MG, Zhang MS, O'Malley Y, Houtman JC, Schlievert PM, Haim H. 2019. The lipid membrane of HIV-1 stabilizes the viral envelope glycoproteins and modulates their sensitivity to antibody neutralization. J Biol Chem 10;295(2):348-362 [PMID 31757809].

  4. McLinden JH, Bhattarai N, Stapleton JT, Chang Q, Kaufman TM, Cassel SL, Sutterwala FS, Haim H, Houtman JC, Xiang J. 2017. Yellow Fever Virus, but Not Zika Virus or Dengue Virus, Inhibits T-Cell Receptor-Mediated T-Cell Function by an RNA-Based Mechanism, J Infect Dis 27;216(9):1164-1175 [PMID 28968905].

  5. Johnson J, Zhai Y, Salimi H, Espy N, Eichelberger N, DeLeon O, O'Malley Y, Courter J, Smith 3rd AB, Madani N, Sodroski J, Haim H. 2017. Induction of a Tier-1-like Phenotype in Diverse Tier-2 Isolates by Agents that Guide HIV-1 Env to Perturbation-sensitive, Non-native States, J Virol 10;91(15):e00174-17 [PMID 28490588].

  6. DeLeon O, Hodis H, O'Malley Y, Johnson J, Salimi H, Zhai Y, Winter E, Remec C, Eichelberger N, Van Cleave B, Puliadi R, Harrington RD, Stapleton JT, Haim H. 2017. Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model, PLoS Biol 15(4):e2001549 [PMID 28384158].

  7. Yen PJ, Herschhorn A, Haim H, Salas I, Gu C, Sodroski J, Gabuzda D. 2014. Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission, J Virol 88(9):5014-28 [PMID 24554659].

  8. McGee K, Haim H, Korioth-Schmitz B, Espy N, Javanbakht H, Letvin N, Sodroski J. 2014. The selection of low envelope glycoprotein reactivity to soluble CD4 and cold during simian-human immunodeficiency virus infection of rhesus macaques, J Virol 88(1):21-40 [PMID 24131720].

  9. Haim H, Salas I, Sodroski J. 2013. Proteolytic processing of the human immunodeficiency virus envelope glycoprotein precursor decreases conformational flexibility, J Virol 87(3):1884-9 [PMID 23175369].

  10. Haim H, Salas I, McGee K, Eichelberger N, Winter E, Pacheco B, Sodroski J. 2013. Modeling virus- and antibody-specific factors to predict human immunodeficiency virus neutralization efficiency, Cell Host Microbe 14(5):547-58 [PMID 24237700].

© 2020 Haim Lab